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Adams, Erin J.
One or more keywords matched the following properties of Adams, Erin J.
PropertyValue
keywords T Cells
overview Our laboratory is interested in the molecular signals that are used by the immune system to distinguish healthy from unhealthy tissue. Many of our projects focus on “unconventional” T cell recognition, involving ?d T cells, Natural Killer T cells and Muscosal-Associated Invariant T (MAIT) cells and antigen presentation by nonclassical or MHC-like proteins. Our strengths are in biochemistry, structural biology, protein engineering and cellular assays that will reveal the fundamental principles behind how effector cells of the immune system regulate human disease. We have a high level of expertise in studying molecular recognition of T cells, particularly unconventional T cells outside the canonical CD4+/CD8+ lineage and structure function of antigen-presenting molecules.
One or more keywords matched the following items that are connected to Adams, Erin J.
Item TypeName
Concept Antigen-Presenting Cells
Concept Adenosine Triphosphate
Concept Cell Line, Transformed
Concept Antigens, Differentiation, T-Lymphocyte
Concept Cell Differentiation
Concept Pan troglodytes
Concept Cell Membrane
Concept Clone Cells
Concept Dendritic Cells
Concept Terminology as Topic
Concept Killer Cells, Natural
Concept Immune Tolerance
Concept Histocompatibility Testing
Concept Mice, Transgenic
Concept Mycobacterium tuberculosis
Concept HeLa Cells
Concept Protein Processing, Post-Translational
Concept Receptors, Cell Surface
Concept Receptors, Antigen, B-Cell
Concept Salmonella typhimurium
Concept Thailand
Concept Thermodynamics
Concept Tryptophan
Concept Tumor Necrosis Factor-alpha
Concept Transduction, Genetic
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Tumor Cells, Cultured
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept CD4-Positive T-Lymphocytes
Concept T-Lymphocyte Subsets
Concept Protein Structure, Tertiary
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Receptor-CD3 Complex, Antigen, T-Cell
Concept CD8-Positive T-Lymphocytes
Concept Cell Proliferation
Concept Protein Transport
Concept Epitopes, T-Lymphocyte
Concept Jurkat Cells
Concept Primary Cell Culture
Concept Transport Vesicles
Concept Receptors, NK Cell Lectin-Like
Concept HEK293 Cells
Concept Natural Killer T-Cells
Concept Kruppel-Like Transcription Factors
Concept T-Lymphocytes, Cytotoxic
Concept Temperature
Concept Transfection
Concept Lymphoma, T-Cell
Concept Receptors, Natural Killer Cell
Concept NK Cell Lectin-Like Receptor Subfamily C
Concept K562 Cells
Concept T-Lymphocytes, Regulatory
Concept Basic Helix-Loop-Helix Transcription Factors
Concept Transcriptome
Concept NK Cell Lectin-Like Receptor Subfamily A
Concept Lectins, C-Type
Concept Thymocytes
Concept Cell Line, Tumor
Concept Forkhead Transcription Factors
Concept Cell Line
Concept Cells, Cultured
Concept Receptors, Antigen, T-Cell
Concept T-Lymphocytes
Concept Thymus Gland
Concept Tuberculosis
Concept Neoplastic Stem Cells
Concept Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Concept Signal Transduction
Concept Tuberculosis Vaccines
Concept NK Cell Lectin-Like Receptor Subfamily D
Concept Electrochemical Techniques
Academic Article Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.
Academic Article African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity.
Academic Article The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.
Academic Article ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion.
Academic Article The molecular basis for modulation of human V?9Vd2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Academic Article The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR.
Academic Article Natural inactivation of a common HLA allele (A*2402) has occurred on at least three separate occasions.
Academic Article Episodic evolution and turnover of HLA-B in the indigenous human populations of the Americas.
Academic Article A novel, nonclassical MHC class I molecule specific to the common chimpanzee.
Academic Article Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes.
Academic Article NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C.
Academic Article Genomic analysis of common chimpanzee major histocompatibility complex class I genes.
Academic Article A T cell receptor goes public.
Academic Article Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802].
Academic Article Analysis of a successful immune response against hepatitis C virus.
Academic Article Peptides bound endogenously by HLA-Cw*0304 expressed in LCL 721.221 cells include a peptide derived from HLA-E.
Academic Article A major histocompatibility complex class I allele shared by two species of chimpanzee.
Academic Article Species-specific evolution of MHC class I genes in the higher primates.
Academic Article Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Academic Article Antigen recognition determinants of gammadelta T cell receptors.
Academic Article How the T cell receptor sees antigen--a structural view.
Academic Article High-level bacterial secretion of single-chain alphabeta T-cell receptors.
Academic Article Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes).
Academic Article Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
Academic Article Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
Academic Article Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells.
Academic Article Recognition of lyso-phospholipids by human natural killer T lymphocytes.
Academic Article An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.
Academic Article Evolution of the V, D, and J gene segments used in the primate gammadelta T-cell receptor reveals a dichotomy of conservation and diversity.
Academic Article Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human ?d T-cell subset.
Academic Article The yin and yang of CD1d recognition.
Academic Article CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.
Academic Article The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.
Academic Article Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.
Academic Article Highly stereocontrolled total synthesis of ß-D-mannosyl phosphomycoketide: a natural product from Mycobacterium tuberculosis.
Academic Article Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.
Academic Article The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor.
Academic Article Evidence for an HLA-C-like locus in the orangutan Pongo pygmaeus.
Academic Article Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes.
Academic Article Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Academic Article Diverse antigen presentation by the Group 1 CD1 molecule, CD1c.
Academic Article Expression of CD1c enhances human invariant NKT cell activation by a-GalCer.
Academic Article Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by aß T cells.
Academic Article The CD3 conformational change in the ?d T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
Academic Article Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.
Academic Article MAIT recognition of a stimulatory bacterial antigen bound to MR1.
Academic Article Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them.
Academic Article Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells.
Academic Article The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V?9Vd2 T cells.
Academic Article ?d T cell surveillance via CD1 molecules.
Academic Article High diversity of MIC genes in non-human primates.
Academic Article Sensing of Pyrophosphate Metabolites by V?9Vd2 T Cells.
Academic Article The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles.
Academic Article Introduction to Cellular Immunology Special Issue on ?d T cells.
Academic Article The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity.
Academic Article Human gamma delta T cells: Evolution and ligand recognition.
Academic Article CK-1, a putative chemokine of rainbow trout (Oncorhynchus mykiss).
Academic Article Coevolution of T-cell receptors with MHC and non-MHC ligands.
Academic Article Molecular Analysis of Lipid-Reactive Vd1 ?d T Cells Identified by CD1c Tetramers.
Academic Article RhoB Mediates Phosphoantigen Recognition by V?9Vd2 T Cell Receptor.
Academic Article MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.
Academic Article The presence of HLA-A*2403 and HLA-B*1512 on the same haplotype in a Thai family.
Academic Article A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates V?9Vd2 T Cells and Binds to the HMBPP Site of BTN3A1.
Academic Article Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.
Academic Article V?9Vd2 T cell activation by strongly agonistic nucleotidic phosphoantigens.
Academic Article Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.
Academic Article Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1.
Academic Article Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V?9Vd2 T cell activation.
Academic Article The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution.
Academic Article Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins.
Academic Article MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.
Academic Article Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires.
Academic Article Butyrophilin3A proteins and V?9Vd2 T cell activation.
Academic Article Generation and molecular recognition of melanoma-associated antigen-specific human ?d T cells.
Academic Article Casting a wider net: Immunosurveillance by nonclassical MHC molecules.
Academic Article TCR-pMHC bond conformation controls TCR ligand discrimination.
Academic Article MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
Academic Article Production of MR1 Tetramers Loaded with Microbial Ligands.
Academic Article Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive V?9Vd2 T cell subset.
Academic Article Diversity in recognition and function of human ?d T cells.
Academic Article Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration.
Academic Article Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.
Academic Article How Tim proteins differentially exploit membrane features to attain robust target sensitivity.
Academic Article The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
Academic Article Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.
Concept Tumor Necrosis Factor alpha-Induced Protein 3
Concept Mucosal-Associated Invariant T Cells
Academic Article CRISPR screens decode cancer cell pathways that trigger ?d T cell detection.
Academic Article Ligand-induced segregation from large cell-surface phosphatases is a critical step in ?d TCR triggering.
Academic Article Biochemical and biophysical characterization of natural polyreactivity in antibodies.
Academic Article ?d T cell explorations seek terra firma.
Academic Article Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells.
Academic Article Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.
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